Welcome to the Ulijn Group website. Our lab is focused on the use of simple versions of the molecular building blocks of life to produce materials and systems with controllable structural, photonic, electronic, and biological properties. These properties open up wide-ranging applications in energy, biomedicine, environmental protection, food, cosmetics, and personal care. [Group Members and Full Biography]
We Are Recruiting!
@asrc_gc is seeking to recruit two highly motivated postdoctoral scholars to research systems-based design of biomolecular modalities and materials. Researchers who have experience or interests that bridge computation/theory and experiment are especially encouraged to consider these positions.
Come and join us in NYC! Apply here.
Intrinsic Fluorescence from Dynamic Interactions
Research in biological condensed phases has exploded over the past decade. A framework of understanding relating to how sequence dictates phase behavior in biological systems is now emerging. However, there are still gaps in understanding at molecular level that permit rational, design of peptide sequences that display sequence-controlled phase behaviors. In our new paper we used the information available from various biological and bioinspired systems described in the literature to design simple de novo repeat sequences that form dynamic interacting peptide networks. Our designs are composed of repeats of tripeptide spacers (GSG, SGS, GLG) interspersed by a pattern of adhesive amino acids (R/H and Y). We show, using a combination of computation and experiment, that spacer editing is sufficient to direct backbone structuring and phase behavior. Unexpectedly, the droplets showed intrinsic fluorescent behavior that was dictated by the peptide sequence.[More Papers]